Predicting PROTAC degradation activity and selectivity of effective E3 ligase through harnessing a combination of AtomPair fingerprints and multiple machine learning algorithms
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Proteolysis targeting chimeras (PROTACs) are drugs that recruit target proteins and E3 ligases to leverage the ubiquitin-proteasome system (UPS) for specific degradation of proteins. This approach has received significant attention because of their ability to ... ...
