In silico, structural and functional characterization of Asp-175 and Phe-169 to regulate catalytic efficiency of NAD synthetase in MRSA
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NAD synthetase in methicillin resistant Staphylococcus aureus is crucial for synthesising NAD+ by converting deamido-NAD+ using ammonia and ATP. Ammonia as one of the substrates is transported as ammonium ion (NH4+) through a tunnel to the enzyme active site. ... ...
