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Antagonists of platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) as rationale and therapeutic potential of combination cancer therapy

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Platelet-Derived Growth Factor (PDGF)/Platelet-Derived Growth Factor Receptor (PDGFR) are key regulators in the complex network of signaling from Receptor Tyrosine Kinases (RTKs). PDGFR has historically been considered an attractive therapeutic target given it... ...