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Somatic mutation profiling by NGS-based liquid biopsy in advanced non-small cell lung cancer: frequency, clinical correlates, and prognostic significance

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Background: Liquid biopsy-based next-generation sequencing (NGS) of plasma cell-free DNA (cfDNA) - including its tumour-derived fraction known as circulating tumor DNA (ctDNA) - enables non-invasive, comprehensive mutational prof... ...