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Spatial transcriptomics links hippocampal synaptic remodeling to microglial phagocytosis in synucleinopathy

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Introduction: Synucleinopathies, including Parkinson's disease (PD) and Lewy body dementia (LBD), are characterized by misfolding and aggregation of α-synuclein (α-syn) into Lewy bodies, a key pathological hallmark. These diso... ...