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Disrupting the mtr-operon in M. acetivorans enables methyl-reducing methanogenesis with hydrogen and serine as the alternative electron donors

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Methanosarcina acetivorans is a model methanogen because of its metabolic versatility and genetic tractability. This microbe is not known to natively utilize hydrogen as a catabolic electron donor, despite its genome encoding hydrogenases, and the fact that th... ...