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Long-term inactivation mediated by different FGF-A homologues on heterologously expressed NaV1.2 currents

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A-isoforms of cytosolic growth factor homologous factors (FGF11-14) mediate long-term inactivation (LTI) of voltage-dependent sodium (NaV) channels. LTI is a rapid onset process that is competitive with the fast inactivation (IF) intrinsic to NaV channels, wit... ...