Mechanistic elucidation of strictosidine synthase-catalyzed Pictet-Spengler reaction for rare piperazine-indole scaffold formation
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Strictosidine synthase (STR) is an enzyme catalyzing the Pictet-Spengler (PS) reaction between tryptamine and secologanin to generate strictosidine. The product is a key intermediate in the biosynthesis of numerous indole alkaloids in plants, many of which exh... ...
