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Structural determinants at KCNE4 position 145 govern Kv1.3 channel function

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Kv1.3 channels participate in the activation and proliferation of leukocytes. The KCNE4 regulatory subunit associates with the channel and functions as a negative regulator. KCNE4, via its transmembrane and C-terminal domains, interacts with Kv1.3, impairing f... ...