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[Antibiotic Penetration into the Central Nervous System: Decoding the Blood: Brain Barrier and Antibiotics through "Structure" to Inform Therapeutic Strategy]

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Clinical outcomes of central nervous system (CNS) infections are determined by not only pathogen coverage but also whether an antibiotic can cross the blood-brain barrier (BBB) to achieve sufficient exposure at the target site. The BBB is a prototypical exampl... ...