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Crocin mitigates colistin-induced toxicity in HEK-293 cells through antioxidant and antiapoptotic mechanisms

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Objective: The glycopeptide antibiotic colistin (polymyxin E) causes dose-dependent nephrotoxicity. The pathophysiology of colistin-induced nephrotoxicity involves processes such as ischemia, inflammation, and apoptosis. By allev... ...