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Development and Characterization of N-Acetylcysteine-Conjugated PAMAM Dendrimers: Biophysical Evaluation of Their Interactions with Proteins and Drug Delivery Applications

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Poly(amidoamine) dendrimers (PAMAM) have been explored extensively for targeted drug delivery. Functionalization of the PAMAM dendrimer with N-acetyl cysteine (NAC) may reduce the toxicity associated with positively charged dendrimers and enable targeted deliv... ...