TiCl4-Promoted Intramolecular Friedel-Crafts Cyclization of α-Keto-phenylbutanoates: Synthesis of Substituted Indane and Indene Derivatives
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We report a TiCl4-mediated intramolecular Friedel-Crafts type cyclization that provides convenient access to functionalized indane and indene derivatives. Reaction of α-ketoester derivatives bearing a phenylethyl side chain with 1.2 equiv of TiCl4 in CH2Cl2 a... ...
