Discovery of Hsp70 inhibitors for allosteric dissociation of the Hsp70/BAG3 complex via structure-based de novo design
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Protein-protein interaction (PPI) with cochaperones could induce conformational changes of Hsp70. The Hsp70/BAG3 PPI shows tumor specificity and could be regarded as potential targets for cancer therapy. In this paper, a de novo structure-based design was carr... ...
