A useful guide for medicinal chemists to design PknG inhibitors: structure-activity relationships, structural requirements and molecular dynamics simulations
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Although treatable, tuberculosis remains a leading cause of death, and multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains have intensified its burden. The serine/threonine kinase G (PknG) of Mycobacterium tuberculosis is an attractive targe... ...
