Reprogramming transgenes reactivation in AML-M5-iPSCs causes doxorubicin resistance in differentiated monocytic-like cells
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Acute monocytic leukaemia (AML-M5) disease models are scarce. To address this, we reprogrammed THP-1 cells from a patient into AML-M5-specific induced pluripotent stem cells (AML-M5-iPSCs) and differentiated them into monocytic-like cells. Unexpectedly, reprog... ...
