A Combination of Oxidative Stress-Induced DNA Damage and NAD+ Synthesis Inhibition Induces Synthetic Lethality in A549 Cells
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Nicotinamide adenine dinucleotide (NAD+) is an important coenzyme involved in various redox reactions. Further, NAD+ is a substrate for poly-ADP-ribose polymerase (PARP). DNA single-strand break (SSB) induces PARP auto-ADP-ribosylation and recruits DNA repair ... ...
