Glucosylated Thiamphenicol: A new veterinary antimicrobial prodrug resistant to bacterial enzymatic inactivation - In vitro and In vivo evaluation using Galleria mellonella larval model infected Salmonellaenterica
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Thiamphenicol (TAM) is an amphenicol antibiotic widely used in veterinary medicine, whose efficacy is increasingly compromised by enzymatic inactivation mediated by chloramphenicol acetyltransferases (CATs). These enzymes acetylate the 3-hydroxyl group of phen... ...
