Multiscale stochastic modeling for calcium dynamics in cardiac electrophysiology: assessing whole-cell model reliability under phosphorylation and LCC downregulation
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Intracellular calcium (Ca2+) dynamics drives contractile function in cardiac myocytes. In particular, L-type Calcium Channels (LCCs) and Ryanodine Receptors (RyRs) are organized in microdomains, where LCCs trigger substantial Ca2+ release from the Sarcoplasmic... ...
