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Novel Piperine derivatives containing substituted Benzamide fragments: Design, synthesis, anti-breast cancer activity, and mechanistic study on the PI3K/AKT/mTOR pathway

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Breast cancer is the most prevalent malignant tumor among women worldwide, and recurrence, metastasis, and drug resistance remain major challenges that compromise treatment efficacy and patient prognosis. Piperine has been reported to possess antitumor potenti... ...