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Synthesis and Preclinical Evaluation of [18F]AlF-NOTA-A2P-GPC3P for Imaging of GPC3

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To develop an effective GPC3-targeted PET probe for tumor imaging, [18F]AlF-NOTA-A2P-GPC3P was synthesized by introducing the hydrophilic linker A2P into the L5 peptide scaffold. The probe was efficiently radiolabeled using the [18F]AlF method, exhibiting high... ...