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Diagnostic accuracy of alpha-defensin ELISA and lateral flow assays for periprosthetic joint infection: a systematic review and meta-analysis

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Background: Alpha-defensin (AD) is a synovial biomarker that can be used in the diagnosis of periprosthetic joint infection (PJI). Two testing modalities are available: the laboratory-based enzyme-linked immunosorbent assay (ELISA) and the point-of-care (POC) ... ...