Discovery of potent and highly selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for treating diabetic nephropathy
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Inhibition of glucose reabsorption by SGLT2 in the kidney is a promising strategy for the treatment of diabetic nephropathy. Adverse side effects of SGLT1 inhibition can be reduced by selective inhibition of SGLT2. Here, we developed an integrated virtual scre... ...