Heparan sulfate buffers the bone resorptive activity of cathepsin K in bone homeostasis
{{output}}
To understand the physiological significance of the interaction between Cathepsin-K (CtsK) and heparan sulfate (HS) in bone resorption, we manipulated HS-CtsK interaction genetically by mutating three basic residues of CtsK responsible for binding HS. This kno... ...
