IXI triplet residues within the Env-V3 tip can influence the replication potential of R5-tropic HIV-1
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The HIV-1 envelope glycoprotein (Env)-gp120 plays a critical role in viral entry by binding to the receptor CD4 and coreceptors CCR5/CXCR4. The V3 loop in CCR5-tropic HIV-1 Env-gp120 is a key domain responsible for interacting with CCR5. Based on virus mutatio... ...
