Somatic cancer variants enriched in Alzheimer's disease microglia-like cells drive inflammatory and proliferative states
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Alzheimer's disease (AD) is a neurodegenerative condition characterized by microglia-mediated neuroinflammation. Deep (>1,000×) panel sequencing of 311 brain samples revealed enrichment of somatic single-nucleotide variants (sSNVs) in cancer driver genes in ... ...
