Targeting a Unique Cysteine Residue to Achieve Isoform-Selective Inhibition of the Proline Biosynthetic Enzyme Pyrroline-5-Carboxylate Reductase 2
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Proline metabolism is selectively altered in cancer cells, providing ATP, redox balance, and proline for cell growth. The final enzyme of proline biosynthesis is Δ1-pyrroline-5-carboxylate (P5C) reductase (PYCR), which catalyzes the NAD(P)H-dependent reductio... ...
