Discovery of 1H-pyrazolo[3,4-d]pyrimidin-4-ylamine derivatives as potent PI3Kδ/BTK dual-target inhibitors for the treatment of B-cell lymphoma
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B-cell lymphoma (BCL) is a hematological system malignant tumor with a relatively high incidence, and PI3Kδ and BTK play an important role in the development of BCL. In the preliminary investigation, we found that when the PI3K inhibitor and the BTK inhibitor... ...
