Towards AI-driven prediction of HTT CAG size in super-expanded human spiny projection neurons from Huntington disease donors
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Somatic instability (SI) of the CAG tract in HTT is a major driver of neurodegeneration of Spiny Projection Neurons (SPNs), the primary neuronal subtype affected in Huntington's disease (HD). SPNs can accumulate hundreds of CAG repeats during a patient's lif... ...
