RABOTS: A Randomized Adaptive Bayesian Optimization Two-Stage Seamless Design for Dose Optimization and Proof-of-Concept Evaluation
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Dose optimization (DO) is a significant paradigm in clinical trials, with the goal of identifying an optimal dose that preserves maximal efficacy while minimizing toxicity. In this paper, we propose a Randomized Adaptive Bayesian Optimization Two-stage Seamles... ...
