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UHRF1-mediated DNA 5-mC modification drives super-enhancer redistribution and impedes osteogenesis via TGM2-regulated autophagic flux in senile osteoporosis

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Introduction: Senile osteoporosis (SOP) is an age-related skeletal disorder characterized by progressive bone mineral density loss and deteriorated bone microarchitecture, imposing significant burdens on aging populations. Impair... ...