Biosynthesis of the africane-type sesquiterpenoid ophioceric acid involves a cytochrome P450 mediated enone formation
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Ophioceric acid (1) is a representative member of africane-type sesquiterpenoids featured with a 5/7/3 tricyclic skeleton. Guided by retrobiosynthesis, we mined the biosynthetic gene cluster of 1 from the fungus Trichoderma harzianum. Based on the results from... ...
