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Natural killer cells labeled with radionuclide-embedded double-layer gold nanoparticles conjugated to a mitochondrial localization sequence for PET/CT imaging and NK cell-based immunotherapy

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Background: Noninvasive, sensitive monitoring of natural killer (NK) cells in vivo remains challenging due to limited nanoparticle uptake. We developed a radionuclide-embedded double-layer gold nanoparticle (RI-DLGNP) platform la... ...