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Mast Cell Activation Syndrome: Quantification of Mast Cells Across Conditions Reveals Limited Diagnostic Utility of Mast Cell Counts and Tryptase Depletion Index

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Context.—: Mast cell enumeration in gastrointestinal biopsies is commonly requested to diagnose mast cell activation syndrome (MCAS) or systemic mastocytosis (SM) with gastrointestinal (GI) involvement. However, mast cell number... ...