Chronic obstructive pulmonary disease as a double-edged sword-reshaping NSCLC immunotherapy paradigms
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Chen et al. demonstrate that NSCLC patients with COPD exhibit superior anti-PD-1 responses through a distinctive immunological mechanism. COPD-driven epithelial remodeling expands CXCL14+ basal-like tumor cells, which orchestrate CXCL9+ macrophage recruitment ... ...
