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Effects of pirfenidone and fisetin on apoptosis and oxidative stress mechanisms in heart tissue of bleomycin-induced pulmonary fibrosis

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Bleomycin (BLM) is a chemotherapeutic agent that has been demonstrated to induce severe pulmonary and cardiac toxicity. Pirfenidone (PFD) is an established antifibrotic drug, while fisetin (FST) is a naturally occurring cardioprotective flavonol. The present s... ...