Effects of Repeated Smoking and Quitting Cigarettes on Plasma Concentrations of Clozapine and Its N-Desmethyl and N-Oxide Metabolites in a Japanese Patient With Schizophrenia
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Clozapine (CLZ) is used for treatment-resistant schizophrenia. However, its pharmacokinetics in Japanese patients with schizophrenia have not been well described. Smoking affects the activities of cytochrome P450 (CYP), which mainly metabolizes CLZ, and patien... ...
