Biophysical and biochemical studies support PHD inhibitor development as a TPI deficiency therapy
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Triosephosphate isomerase deficiency (TPI Df) is an ultra-rare genetic enzymopathy. Previously, the TPIR5G allele was found to cause TPI Df when combined with a null allele. Here we report a 1.15 angstrom TPIR5G crystal structure providing insight into disease... ...
