Structure-guided modification of a lead cholinesterase-targeting oxime to improve peripheral site binding
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Based on our previous study on N‑substituted 2-hydroxyiminoacetamides as cholinesterase-targeting ligands, which highlighted 2-hydroxyimino-N-(3-(4-((2-methyl-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-1-phenylpropyl)acetamide as lead compound because of... ...
