Systematic mining and engineering of signal peptides to achieve efficient secretion of cephalosporin C acylase in Escherichia coli
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Cephalosporin C acylases (CCAs) catalyze the hydrolysis of cephalosporin C to 7-aminocephalosporanic acid, a key intermediate for semisynthetic cephalosporin antibiotics. The functional secretion of heterologous CCAs in Escherichia coli is often constrained by... ...
