Non-Catalyzed Cascade Double Imination Reaction of 2‑Fluoro-alk-3-yn-1-ones: Sustainable Synthesis of 3‑Fluoro-1,5-benzodiazepines
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The cascade reactions of 2-fluoroalk-3-yn-1-ones with o-phenylenediamines provide an effective synthetic method with high atom economy for the preparation of diversely substituted 3-fluoro-3H-benzo-[b]-[1,4]-diazepines (52-81%). This noncatalytic and sustainab... ...
