Mechanistic Basis of Cholesterol Binding and Transfer in NPC2: Insights From Molecular Dynamics Simulations
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The Niemann-Pick type C (NPC) disease is characterized by impaired function of the lysosomal proteins NPC1 or NPC2. The soluble NPC2 protein is believed to transport cholesterol to the larger, membrane-bound NPC1, thereby maintaining cholesterol homeostasis; d... ...
