Design and synthesis of O-benzoyl amidoxime derivatives as novel TLR2/1 agonists with potent anti-radiation activity in mice
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In this paper, a series of O-benzoyl amidoxime derivatives were designed and synthesized as TLR2/1 small-molecule agonists. Among the target compounds, A-18 exhibited potent activity in human TLR2 and TLR1 transient-cotransfected HEK 293 T cells. Furthermore, ... ...
