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Siah-1 is Critical for Hypoxia-Induced Lifespan Extension in Caenorhabditis elegans by Regulating the Expression of SKN-1

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Introduction: Hypoxia has been shown to extend lifespan in Caenorhabditis elegans through mechanisms involving HIF-1 and DAF-16, but the interplay with SKN-1/Nrf, a key regulator of oxidative stress responses, remains complex. St... ...