Mode of action (MOA) for nasal tumors induced by methyl isothiocyanate (MITC) in Sprague Dawley rats
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Methyl isothiocyanate (MITC), a soil fumigant, induced nasal tumors in Sprague Dawley rats exposed by inhalation to a high concentration (20 ppm), but not at 0.5 or 5 ppm. In an inhalation study (1 day, 5 days, or 4 weeks) with MITC, nasal lesions were observe... ...
