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Rapid synthesis and antimicrobial evaluation of triazole-modified calix[4]arenes via click chemistry

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The current study comprises the synthesis of para-tert-butylcalix[4]arene 2 bearing a terminal alkyne group via alkylation of para-tert-butylcalix[4]arene (1) with 4-bromo-1-butyne in the presence of K2CO3. A series of aryl azides, namely benzyl azide (3a), pe... ...