Unlocking the Anticancer Potential of New Spirooxindoles via p53-MDM2/MDMX Dual Inhibition: In Vitro and In Silico Assessments
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Blocking the p53-MDM2 and/or p53-MDMX protein-protein interaction (PPI) by small-molecule inhibitors has been tracked as a potentially effective cancer treatment approach. Herein, we present the discovery of a new series of spirooxindole-tethered pyrazolopyrid... ...
