Opioidergic and GABAergic mechanisms underlie the anti-nociceptive effects of adamantane amino thiazole derivatives: synthesis, toxicity evaluation and mechanistic insights using standard pre-clinical models
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The present study involves the synthesis, toxicity assessment and investigation of anti-nociceptive potential of two adamantane amino thiazole derivatives (AATD), including [N-((1s, 3s)-adamantan-1-yl)-4-(4-bromophenyl)thiazol-2-amine] (AATD1) and [2-(2-(((1s,... ...