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Computational modeling-assisted discovery of the structural effects of phenylpropanoid derivatives on intracellular anti-Trypanosoma cruzi activity

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Previous investigations have demonstrated that n-hexacosyl p-coumarate, a natural product isolated from the Brazilian plant Baccharis sphenophylla, exhibits activity against the extracellular (trypomastigote) forms of Trypanosoma cruzi. Structural modification... ...