3-Substituted Lawsones from Indanone Chalcones: Application of the House-Meinwald Rearrangement (HMR) for Chemoselective Ring Expansion
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3-Substituted lawsones were synthesized via a chemoselective HMR-enabled ring expansion of indanone substrates. The transformation proceeds through epoxidation, quinone methide-type intermediate formation, ring expansion, and benzylic sp3 C-H oxidation. This o... ...
